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Paget’s disease of bone

  • Overview


    Paget’s disease of bone disrupts the natural bone remodeling process, where old bone is replaced by new bone tissue. This condition leads to weakened and deformed bones over time, often affecting the pelvis, skull, spine, and legs predominantly.

    The risk of Paget’s disease rises with age and a family history of the disorder. Interestingly, though, the prevalence of the disease has diminished in recent years, and its severity has also lessened, a trend still not fully understood by the medical community. Potential complications encompass fractures, hearing impairment, and compression of spinal nerves.

    Central to treatment are bisphosphonates, the same class of medications used to fortify bones compromised by osteoporosis. These medications help stabilize bone remodeling. Surgical intervention might be necessary if complications arise.

    It’s important to note that Paget’s disease of bone warrants medical attention, monitoring, and management to mitigate potential complications and enhance quality of life.

  • Symptoms


    The majority of individuals with Paget’s disease of bone experience no apparent symptoms. However, when symptoms do emerge, the most common complaint is often bone pain.

    This condition accelerates the process of new bone generation, resulting in bone tissue that is less organized and weaker than normal bone. Consequently, this rapid remodeling can lead to bone pain, deformities, and fractures.

    Paget’s disease may manifest in isolated areas of the body or spread more widely. The specific signs and symptoms experienced will depend on the affected body part:

    • Pelvis: Paget’s disease in the pelvis may result in hip pain.
    • Skull: Excessive bone growth in the skull can lead to hearing loss or recurring headaches.
    • Spine: In cases where the spine is affected, there may be compression of nerve roots, causing sensations of pain, tingling, and numbness in an arm or leg.
    • Leg: Weakening of the leg bones can cause curvature, leading to a bowlegged appearance. Enlarged and irregularly shaped leg bones may place added strain on nearby joints, potentially contributing to the development of osteoarthritis in the knee or hip.

    As the presence and severity of Paget’s disease can vary widely among individuals, maintaining a vigilant awareness of potential symptoms, seeking appropriate medical evaluation, and considering necessary interventions are essential for managing complications and promoting overall well-being.

  • When to see a doctor


    Abnormal symptoms may be a warning sign of potential dangerous diseases. Please contact our team of doctors immediately for detailed advice and update the most accurate and appropriate health care method.

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  • Causes


    The precise cause of Paget’s disease of bone remains elusive. Researchers speculate that a combination of environmental and genetic elements may play a role in its development. Multiple genes seem to be associated with the susceptibility to this disease.

    While not universally accepted, some scientists propose a potential link between Paget’s disease of bone and a viral infection within bone cells. However, this theory remains a subject of debate and controversy within the scientific community. Further investigations are necessary to gain a comprehensive understanding of the underlying mechanisms behind this condition.

  • Risk factors


    There are several factors that can elevate your risk of developing Paget’s disease of bone:

    • Age: Individuals over the age of 50 are more prone to developing the disease.
    • Sex: Men are more frequently affected compared to women.
    • National Origin: Paget’s disease of bone is more prevalent in regions like England, Scotland, central Europe, and Greece, as well as in countries settled by European immigrants. However, its occurrence is uncommon in Scandinavia and Asia.
    • Family History: If you have a family member with a history of Paget’s disease of bone, your risk of developing the condition is higher.
  • Prevention


    Currently, there is no known way to prevent Paget’s disease of bone. However, there are some general strategies and lifestyle choices that may help manage the condition and reduce its impact on your overall health:

    1. Healthy Lifestyle: Adopting a healthy lifestyle that includes a balanced diet rich in calcium and vitamin D can contribute to bone health. Regular exercise, particularly weight-bearing activities like walking, jogging, and resistance training, can help maintain bone strength and density.
    2. Bone Health Awareness: Being aware of your bone health and risk factors can lead to early detection and management of Paget’s disease. If you have a family history of the condition or are at a higher risk due to other factors, consider discussing your concerns with a healthcare professional.
    3. Regular Check-ups: Routine visits to your healthcare provider can help monitor your bone health and detect any changes or symptoms of Paget’s disease early on. This can lead to timely interventions and treatments if necessary.
    4. Medication Management: If you’ve been diagnosed with Paget’s disease or are at a higher risk, it’s important to follow your healthcare provider’s recommendations regarding medications. Medications can help regulate bone remodeling and reduce symptoms.
    5. Fall Prevention: As Paget’s disease can affect bone strength and increase the risk of fractures, taking steps to prevent falls is crucial. This includes keeping your home well-lit, using assistive devices if needed, and being cautious on slippery surfaces.
    6. Regular Bone Density Testing: Periodic bone density testing, such as dual-energy X-ray absorptiometry (DEXA) scans, can help assess your bone health and detect any changes in bone density. Your healthcare provider can use these results to guide treatment decisions.
    7. Consult a Specialist: If you’re at risk of developing Paget’s disease due to genetic factors or other reasons, consider consulting a specialist such as a rheumatologist or an endocrinologist. They can provide expert guidance on managing and monitoring your bone health.
  • *Please note that the information provided in the article is for reference purposes only. It is essential to consult a doctor before applying any of the suggestions mentioned.

Content Details

Medical info from Mayo Clinic, for reference only. Visit Hoan My for better advice.

Last updated on: 06/08/2023